July 5, 2022

Kidney Transplant 101

Kidney transplant patients have a lower risk of primary CMV compared to other organ transplant recipients due to a lower latent viral load in the renal graft tissue. The net state of immunosuppression and epidemiological exposures of the recipient of a kidney transplant determines the risk of infection at any time. A traditional timeline has been used to predict infection patterns after organ transplantation. This timeline has changed in recent years with changes in immunosuppressive therapy and the routine use of antibacterial and antiviral prophylaxis.

Because these anti-rejection drugs make your body more vulnerable to infection, your doctor may also prescribe antibacterial, antiviral and anti-fungal medicines. It is preferable to get a kidney from a donor whose blood type matches or is compatible with yours. Incompatible blood type transplants are also possible, but require additional pre- and post-transplant medical treatment to reduce the risk of organ rejection. Bone disease (also known as chronic kidney disease, bone and mineral disorder or MBD-CKD) can continue even after your kidney transplant. CKD-MBD occurs due to side effects of medication, previous kidney disease, diabetes, smoking, lack of exercise, menopause or several years of dialysis. Dharnidharka VR, Agodoa LY, Abbott KC. Hospitalization risk factors for bacterial or viral infection in renal transplant recipients: an analysis of USRDS data

Laryngeal, meningeal, skeletal, skin, intestinal and kidney infections are examples of extrapulmonary disorders. A high clinical presumption should be maintained for the diagnosis of urinary tract tuberculosis in recipients of solid organ transplants. The presence of infection of the lower or upper urinary tract with pyuria and hypertension expert witness specialist hematuria in the absence of bacterial isolation in routine cultures should cause urine cultures in specific selective media for the isolation of Mycobacterium tuberculosis. Negative tuberculin skin test or the absence of radiographic chest abnormalities indicating pulmonary tuberculosis rule out tuberculosis in this context.

Kidney transplant recipients were more likely to have an instrumental delivery and there was a trend towards an increase in cesarean section. Four maternal mortality occurred in women with ESRD on dialysis and no maternal mortality occurred in renal transplant patients. Kidney graft failure occurs due to chronic rejection, graft disorders and nephrotoxicity, causing the patient to need dialysis and often a new organ. The development of new therapeutic approaches to prevent chronic rejection is necessary to extend the long-term survival of kidney transplants.

Although these symptoms disappear, the virus remains in the body forever. When suppressed, CMV can reactivate after a kidney transplant and can cause various serious infections, such as pneumonia, eye infections or gastrointestinal disorders. To prevent your body from shedding your donor kidney, you need medicines to suppress your immune system.